Carbohydrates Metabolism: Digestion of carbohydrates, glycolysis and fate of pyruvate in different organisms; tricarboxylic acid (TCA) cycle; pentose phosphate pathway and fate of reduced coenzymes; catabolism of monosaccharides other than glucose; gluconeogenesis, Calvin Benson cycle, Cori cycle, glyoxylate cycle; glycogenesis and glycogenolysis; regulation of carbohydrate metabolism; Diseases of carbohydrate metabolism. Aerobic metabolism of pyruvate, starvation and obesity. The coenzyme role of B vitamins. Changes in nutritional requirement and metabolic rate in injury and disease. Lipids Metabolism: Digestion of triacylglycerols; the different lipases (lipoprotein lipase, hormone-sensitive lipase); fate of glycerol; beta-oxidation of fatty acids; fate of products (acetyl and propionyl CoA, ketone bodies, reduced coenzymes); synthesis of fatty acids triacylglycerol, cholesterol; regulation of metabolism. Protein Metabolism: Digestion of proteins, transamination, deamination and decarboxylation of amino acids and the fate of ammonia (urea cycle) and carbon skeleton; metabolism of specific amino acids (aromatic and sulphur-containing amino acids); synthesis of amino acids; in-born errors of amino acid metabolism; regulation of metabolism. Enzymes as biological catalyst: Enzyme kinetics and concept of rate-determining step. Enzyme specificity and allosteric regulation. Mechanisms of enzyme action and examples. Coenzymes and vitamins. Drugs and their effect on enzymes.

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